Endocrine Abstracts

Disorders of bone mineralization observed in women with ovarian insufficiency are unlikely a simple function of decreased concentration of oestrogens. Published evidence suggests that adipose tissue is a central component within the complex system of metabolic and hormonal interactions responsible for adequate mineralization of the bone. However, to the best of our knowledge, the composite effects of specific substances synthesized within adipose tissue from various anatomical...

Introduction: The question if obesity may protect against osteoporosis is still a matter of discussion. A breakthrough in this debate may be the introduction of a state-of-the-art densitometric software (CoreScan) suitable for fast and accurate volumetry of total body fat (BF), including android (A), female-type (F) and visceral fat (VAT) volumes.Aim: The aim of the study was to analyze an association between bone mineral density (BMD]), concentrations o...

Obesity is an independent risk factor for the development of cardiovascular disease, frequently associated with various metabolic disorders defined as metabolic syndrome. High plasma total homocysteine (Hcy) concentration is now well established as a powerful risk indicator for a wide range of vascular diseases.The aim of this study was to investigate total Hcy levels in obese children and their possible association with both metabolic syndrome and vario...

Introduction: The prevalence of incidentally found adrenal tumors – adrenal incidentalomas (AI) – in imaging procedures and autopsy series is up to 4.5–8.7%. Endocrine and clinical evaluation is carried out to diagnose hormonal function or malignancy of the tumors. Nonfunctional adenomas comprise about 80% of AI. The aim of the study was to identify possible association between various clinical, hormonal and radiological features of nonfunctional AI.<p class...

Introduction: Reduced bone mineral density (BMD) is present in many women with Turner syndrome (TS), while hypo-estrogenism is known to play a vital role in bone mineralization disturbances. It has been suggested that genetic factors play an important role in the regulation of BMD. The aim of this study was to analyze the association between PvuII and XbaI ER-a polymorphisms and BMD in TS patients subjected to estroprogestagen (EP) treatment.Material and...

Introduction: The aim of this study was to verify if genetic factors influence the short- and long-term therapeutic responses to oestroprogestagen (OP) therapy, implemented in girls with functional hypothalamic amenorrhoea (FHA) in order to improve their bone mineral density (BMD).Material and methods: The study included 84 FHA girls who underwent a 4-year sequential OP therapy with 17-β oestradiol and didrogesterone. Changes in the lumbar spine BMD...

There are increasing evidences that leptin, a protein secreted by adipose tissue, may be an important factor contributing to the development of atherosclerosis. In this study, the relationship between plasma leptin levels and markers of inflammation and endothelial activation was investigated in 214 obese nondiabetic children and adolescents. Fasting levels of leptin, C-reactive protein (CRP), fibrinogen (FB), interleukin-6 (IL-6), interleukin-1β (IL-1β), intercellul...

Available evidence suggests that unfavorable changes in the distribution of body fat resulting from hormonal imbalance associated with ovarian insufficiency may exert detrimental effects on bone mineral density (BMD). The aim of this study was to verify if densitometrically determined volumes of visceral (VAT), female (FAT) and android (AAT) adipose tissue influence BMD in women with menstrual disorders, and if these relationships are modulated by endocrine factors. The study ...

Introduction: Acromegaly causes hyperlipidemia and glucose metabolism disturbances what finally results in increased mortality. Correctin of those lipid and glucose disturbances during treatment with long-acting somatostatin analogues was examinated in this study.Material and methods: Eleven patients (9 women and 2 men) with active acromegaly and macroadenoma diagnosed at our Department in the years 2008–2011 underwent monitoring of lipids and gluco...

Objective: Vitamin D deficiency is common in polish population and seem to play role in pathogenesis of some diseases. We looked for correlation between polymorphisms BsmI, TaqI, ApaI and FokI of vitamin D receptor and vitamin D influence on goiter development.Methods: One hundred and fifty two women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood s...